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Haematopoietic SCT in severe autoimmune diseases: updated guidelines of the European Group for Blood and Marrow Transplantation

Identifieur interne : 005C06 ( Main/Exploration ); précédent : 005C05; suivant : 005C07

Haematopoietic SCT in severe autoimmune diseases: updated guidelines of the European Group for Blood and Marrow Transplantation

Auteurs : J. A. Snowden [Royaume-Uni] ; R. Saccardi [Italie] ; M. Allez [France] ; S. Ardizzone [Italie] ; R. Arnold [Allemagne] ; R. Cervera [Espagne] ; C. Denton [Royaume-Uni] ; C. Hawkey [Royaume-Uni] ; M. Labopin [France] ; G. Mancardi [Italie] ; R. Martin [Allemagne] ; J. J. Moore [Australie] ; J. Passweg [Suisse] ; C. Peters [Autriche] ; M. Rabusin [Italie] ; M. Rovira [Espagne] ; Jm Van Laar [Royaume-Uni] ; D. Farge [France]

Source :

RBID : Pascal:12-0258465

Descripteurs français

English descriptors

Abstract

In 1997, the first consensus guidelines for haematopoietic SCT (HSCT) in autoimmune diseases (ADs) were published, while an international coordinated clinical programme was launched. These guidelines provided broad principles for the field over the following decade and were accompanied by comprehensive data collection in the European Group for Blood and Marrow Transplantation (EBMT) AD Registry. Subsequently, retrospective analyses and prospective phase I/II studies generated evidence to support the feasibility, safety and efficacy of HSCT in several types of severe, treatment-resistant ADs, which became the basis for larger-scale phase II and III studies. In parallel, there has also been an era of immense progress in biological therapy in ADs. The aim of this document is to provide revised and updated guidelines for both the current application and future development of HSCT in ADs in relation to the benefits, risks and health economic considerations of other modern treatments. Patient safety considerations are central to guidance on patient selection and HSCT procedural aspects within appropriately experienced and Joint Accreditation Committee of International Society for Cellular Therapy and EBMT accredited centres. A need for prospective interventional and non-interventional studies, where feasible, along with systematic data reporting, in accordance with EBMT policies and procedures, is emphasized.


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Le document en format XML

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<name sortKey="Rabusin, M" sort="Rabusin, M" uniqKey="Rabusin M" first="M." last="Rabusin">M. Rabusin</name>
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<inist:fA14 i1="16">
<s1>BMT Unit, Department of Pediatrics, Institute of Maternal and Child Health Burlo Garofolo</s1>
<s2>Trieste</s2>
<s3>ITA</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Trieste</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Rovira, M" sort="Rovira, M" uniqKey="Rovira M" first="M." last="Rovira">M. Rovira</name>
<affiliation wicri:level="3">
<inist:fA14 i1="17">
<s1>SCT Unit, Hematology Department, Hospital Clinic</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName>
<settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Laar, Jm Van" sort="Laar, Jm Van" uniqKey="Laar J" first="Jm Van" last="Laar">Jm Van Laar</name>
<affiliation wicri:level="1">
<inist:fA14 i1="18">
<s1>Newcastle University</s1>
<s2>Newcastle-Upon-Tyne</s2>
<s3>GBR</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Newcastle University</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Farge, D" sort="Farge, D" uniqKey="Farge D" first="D." last="Farge">D. Farge</name>
<affiliation wicri:level="3">
<inist:fA14 i1="19">
<s1>Department of Internal Medicine, INSERM U 796, Hôpital St Louis</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series>
<title level="j" type="main">Bone marrow transplantation : (Basingstoke)</title>
<title level="j" type="abbreviated">Bone marrow transplant. : (Basingstoke)</title>
<idno type="ISSN">0268-3369</idno>
<imprint>
<date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt>
<title level="j" type="main">Bone marrow transplantation : (Basingstoke)</title>
<title level="j" type="abbreviated">Bone marrow transplant. : (Basingstoke)</title>
<idno type="ISSN">0268-3369</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Autoimmune disease</term>
<term>European directive</term>
<term>European group for blood and marrow transplantation</term>
<term>Hematology</term>
<term>Hematopoietic stem cell transplantation</term>
<term>Recommendation</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>Maladie autoimmune</term>
<term>Directive européenne</term>
<term>Recommandation</term>
<term>Hématologie</term>
<term>Greffe de cellules souches hématopoïétiques</term>
<term>EBMT</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr">
<term>Recommandation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">In 1997, the first consensus guidelines for haematopoietic SCT (HSCT) in autoimmune diseases (ADs) were published, while an international coordinated clinical programme was launched. These guidelines provided broad principles for the field over the following decade and were accompanied by comprehensive data collection in the European Group for Blood and Marrow Transplantation (EBMT) AD Registry. Subsequently, retrospective analyses and prospective phase I/II studies generated evidence to support the feasibility, safety and efficacy of HSCT in several types of severe, treatment-resistant ADs, which became the basis for larger-scale phase II and III studies. In parallel, there has also been an era of immense progress in biological therapy in ADs. The aim of this document is to provide revised and updated guidelines for both the current application and future development of HSCT in ADs in relation to the benefits, risks and health economic considerations of other modern treatments. Patient safety considerations are central to guidance on patient selection and HSCT procedural aspects within appropriately experienced and Joint Accreditation Committee of International Society for Cellular Therapy and EBMT accredited centres. A need for prospective interventional and non-interventional studies, where feasible, along with systematic data reporting, in accordance with EBMT policies and procedures, is emphasized.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Allemagne</li>
<li>Australie</li>
<li>Autriche</li>
<li>Espagne</li>
<li>France</li>
<li>Italie</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
</country>
<region>
<li>Angleterre</li>
<li>Berlin</li>
<li>Catalogne</li>
<li>Grand Londres</li>
<li>Hambourg</li>
<li>Lombardie</li>
<li>Nottinghamshire</li>
<li>Vienne (Autriche)</li>
<li>Île-de-France</li>
</region>
<settlement>
<li>Barcelone</li>
<li>Berlin</li>
<li>Hambourg</li>
<li>Londres</li>
<li>Milan</li>
<li>Nottingham</li>
<li>Paris</li>
<li>Vienne (Autriche)</li>
</settlement>
<orgName>
<li>Université de Nottingham</li>
</orgName>
</list>
<tree>
<country name="Royaume-Uni">
<noRegion>
<name sortKey="Snowden, J A" sort="Snowden, J A" uniqKey="Snowden J" first="J. A." last="Snowden">J. A. Snowden</name>
</noRegion>
<name sortKey="Denton, C" sort="Denton, C" uniqKey="Denton C" first="C." last="Denton">C. Denton</name>
<name sortKey="Hawkey, C" sort="Hawkey, C" uniqKey="Hawkey C" first="C." last="Hawkey">C. Hawkey</name>
<name sortKey="Laar, Jm Van" sort="Laar, Jm Van" uniqKey="Laar J" first="Jm Van" last="Laar">Jm Van Laar</name>
<name sortKey="Snowden, J A" sort="Snowden, J A" uniqKey="Snowden J" first="J. A." last="Snowden">J. A. Snowden</name>
</country>
<country name="Italie">
<noRegion>
<name sortKey="Saccardi, R" sort="Saccardi, R" uniqKey="Saccardi R" first="R." last="Saccardi">R. Saccardi</name>
</noRegion>
<name sortKey="Ardizzone, S" sort="Ardizzone, S" uniqKey="Ardizzone S" first="S." last="Ardizzone">S. Ardizzone</name>
<name sortKey="Mancardi, G" sort="Mancardi, G" uniqKey="Mancardi G" first="G." last="Mancardi">G. Mancardi</name>
<name sortKey="Rabusin, M" sort="Rabusin, M" uniqKey="Rabusin M" first="M." last="Rabusin">M. Rabusin</name>
</country>
<country name="France">
<region name="Île-de-France">
<name sortKey="Allez, M" sort="Allez, M" uniqKey="Allez M" first="M." last="Allez">M. Allez</name>
</region>
<name sortKey="Farge, D" sort="Farge, D" uniqKey="Farge D" first="D." last="Farge">D. Farge</name>
<name sortKey="Labopin, M" sort="Labopin, M" uniqKey="Labopin M" first="M." last="Labopin">M. Labopin</name>
</country>
<country name="Allemagne">
<region name="Berlin">
<name sortKey="Arnold, R" sort="Arnold, R" uniqKey="Arnold R" first="R." last="Arnold">R. Arnold</name>
</region>
<name sortKey="Martin, R" sort="Martin, R" uniqKey="Martin R" first="R." last="Martin">R. Martin</name>
</country>
<country name="Espagne">
<region name="Catalogne">
<name sortKey="Cervera, R" sort="Cervera, R" uniqKey="Cervera R" first="R." last="Cervera">R. Cervera</name>
</region>
<name sortKey="Rovira, M" sort="Rovira, M" uniqKey="Rovira M" first="M." last="Rovira">M. Rovira</name>
</country>
<country name="Australie">
<noRegion>
<name sortKey="Moore, J J" sort="Moore, J J" uniqKey="Moore J" first="J. J." last="Moore">J. J. Moore</name>
</noRegion>
</country>
<country name="Suisse">
<noRegion>
<name sortKey="Passweg, J" sort="Passweg, J" uniqKey="Passweg J" first="J." last="Passweg">J. Passweg</name>
</noRegion>
</country>
<country name="Autriche">
<region name="Vienne (Autriche)">
<name sortKey="Peters, C" sort="Peters, C" uniqKey="Peters C" first="C." last="Peters">C. Peters</name>
</region>
</country>
</tree>
</affiliations>
</record>

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